Table 7 Assessment of the nuclear proteins including FANCD2, RAD51, BRCA2, BRCA1, BRIP1(BACH1) in NCR and CR cervical tumors evaluated both for genomics study set (n = 21) and IHC validation set (n = 24)
Proteins | Cellular localization | NCR % | CR % | NCR/CR ratio | p-value |
|---|---|---|---|---|---|
Genomics study set (n = 21) |  |  |  |  |  |
FANCD2 | nucleus | 32.53 | 15.6 | 2.09 | 0.032 |
RAD51 | nucleus | 14.88 | 7.11 | 2.09 | 0.016 |
BRCA2 | nucleus | 21.11 | 20.81 | 1.01 | 0.868 |
BRCA1 | nucleus | 27.78 | 10.69 | 2.60 | 0.032 |
BRIP1 (BACH1) | nucleus | 40.44 | 10.05 | 4.02 | 0.001 |
IHC validation set (n = 24) |  |  |  |  |  |
FANCD2 | nucleus | 25.34 | 16.22 | 1.56 | 0.011 |
RAD51 | nucleus | 16.87 | 4.86 | 3.47 | 0.000 |
BRCA1 | nucleus | 27.59 | 12.97 | 2.13 | 0.000 |
BRIP1 (BACH1) | nucleus | 30.73 | 14.55 | 2.11 | 0.011 |