Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure

Table 4 Genes involved in the "Role of BRCA1 in DNA Damage Response" pathway with associated p-values obtained from microarray experiment

Ref seq	Gene symbol	Fold regulation (NCR vs CR)	Adjusted p-value	Description
NM_005171	ATF1	1,747	0,013	activating transcription factor 1
NM_000057	BLM	2,430	0,030	Bloom syndrome, RecQ helicase-like
NM_007300	BRCA1	2,225	0,008	breast cancer 1, early onset
NM_000059	BRCA2	1,842	0,011	breast cancer 2, early onset
NM_001018055	BRCC3	1,621	0,016	BRCA1/BRCA2-containing complex, subunit 3
NM_032043	BRIP1	2,353	0,018	BRCA1 interacting protein C-terminal helicase 1
NM_004091	E2F2	2,137	0,048	E2F transcription factor 2
NM_001950	E2F4	-1,791	0,013	E2F transcription factor 4, p107/p130-binding
NM_001018113	FANCB	2,216	0,010	Fanconi anemia, complementation group B
NM_033084	FANCD2	1,613	0,012	Fanconi anemia, complementation group D2
NM_018062	FANCL	1,701	0,031	Fanconi anemia, complementation group L
NM_020937	FANCM	1,923	0,005	Fanconi anemia, complementation group M
NM_139048	HLTF	2,245	0,016	helicase-like transcription factor
NM_002875	RAD51	2,767	0,010	RAD51 homolog (S. cerevisiae)
NM_002913	RFC1	1,723	0,004	replication factor C (activator 1) 1, 145 kDa
NM_139045	SMARCA2	1,659	0,041	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NM_003072	SMARCA4	-1,519	0,026	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

ISSN: 1471-2407