From: Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer
Clinical feature | LDH ≥ 250 U/l | HLTF methylation | HPP1 methylation | NEUROG1 methylation | ||||
---|---|---|---|---|---|---|---|---|
 | n (%) | P | n (%) | P | n (%) | P | n (%) | p |
Total positive | 50 (19) | Â | 41 (16) | Â | 57 (22) | Â | 66 (25) | Â |
Age a | Â | Â | Â | Â | Â | Â | Â | Â |
≤ 65 years | 31 (24) |  | 18 (14) |  | 31 (24) |  | 36 (28) |  |
> 65 years | 19 (15) | 0.055 | 23 (18) | 0.410 | 26 (20) | 0.434 | 30 (23) | 0.372 |
Sex | Â | Â | Â | Â | Â | Â | Â | Â |
Male | 26 (18) | Â | 22 (15) | Â | 34 (23) | Â | 34 (23) | Â |
Female | 24 (21) | 0.528 | 19 (17) | 0.744 | 23 (20) | 0.528 | 32 (28) | 0.397 |
Tumor size a | Â | Â | Â | Â | Â | Â | Â | Â |
T1 | 0 (0) | Â | 2 (13) | Â | 1 (7) | Â | 4 (27) | Â |
T2 | 9 (19) | Â | 3 (6) | Â | 3 (6) | Â | 12 (25) | Â |
T3 | 28 (18) | Â | 25 (16) | Â | 32 (21) | Â | 39 (25) | Â |
T4 | 13 (31) | 0.062 | 11 (27) | 0.080 | 20 (48) | <.0001 | 11 (26) | 0.999 |
Nodal status b | Â | Â | Â | Â | Â | Â | Â | Â |
N0 | 14 (10) | Â | 16 (12) | Â | 13 (9) | Â | 37 (27) | Â |
N1 | 19 (29) | Â | 13 (20) | Â | 23 (35) | Â | 13 (20) | Â |
N2 | 15 (30) | 0.0006 | 11 (22) | 0.139 | 18 (36) | <.0001 | 16 (32) | 0.307 |
Metastatic disease | Â | Â | Â | Â | Â | Â | Â | Â |
M0 | 13 (8) | Â | 20 (12) | Â | 10 (6) | Â | 48 (28) | Â |
M1 | 37 (42) | <.0001 | 21 (24) | 0.013 | 47 (53) | <.0001 | 18 (20) | 0.160 |
Localization | Â | Â | Â | Â | Â | Â | Â | Â |
Colon | 25 (20) | Â | 22 (18) | Â | 33 (27) | Â | 38 (31) | Â |
Sigmoid | 9 (19) | Â | 10 (21) | Â | 8 (17) | Â | 8 (17) | Â |
Rectum | 9 (19) | 0.884 | 9 (10) | 0.151 | 16 (18) | 0.180 | 20 (22) | 0.114 |
Tumor grade c | Â | Â | Â | Â | Â | Â | Â | Â |
G1 & G2 | 22 (17) | Â | 16 (12) | Â | 16 (12) | Â | 37 (28) | Â |
G3 & G4 | 25 (21) | 0.344 | 23 (20) | 0.102 | 37 (32) | 0.0002 | 27 (23) | 0.372 |
UICC stage | Â | Â | Â | Â | Â | Â | Â | Â |
I | 6 (12) | Â | 4 (8) | Â | 2 (4) | Â | 16 (31) | Â |
II | 4 (6) | Â | 11 (16) | Â | 4 (6) | Â | 19 (28) | Â |
III | 3 (6) | Â | 5 (10) | Â | 4 (8) | Â | 13 (25) | Â |
IV | 37 (42) | <.0001 | 21 (24) | 0.049 | 47 (53) | <.0001 | 18 (20) | 0.486 |