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Table 2 Distribution of LDH and methylation of HLTF , HPP1 and NEUROG1 among clinicopathologic features

From: Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer

Clinical feature LDH ≥ 250 U/l HLTF methylation HPP1 methylation NEUROG1 methylation
  n (%) P n (%) P n (%) P n (%) p
Total positive 50 (19)   41 (16)   57 (22)   66 (25)  
Age a         
≤ 65 years 31 (24)   18 (14)   31 (24)   36 (28)  
> 65 years 19 (15) 0.055 23 (18) 0.410 26 (20) 0.434 30 (23) 0.372
Sex         
Male 26 (18)   22 (15)   34 (23)   34 (23)  
Female 24 (21) 0.528 19 (17) 0.744 23 (20) 0.528 32 (28) 0.397
Tumor size a         
T1 0 (0)   2 (13)   1 (7)   4 (27)  
T2 9 (19)   3 (6)   3 (6)   12 (25)  
T3 28 (18)   25 (16)   32 (21)   39 (25)  
T4 13 (31) 0.062 11 (27) 0.080 20 (48) <.0001 11 (26) 0.999
Nodal status b         
N0 14 (10)   16 (12)   13 (9)   37 (27)  
N1 19 (29)   13 (20)   23 (35)   13 (20)  
N2 15 (30) 0.0006 11 (22) 0.139 18 (36) <.0001 16 (32) 0.307
Metastatic disease         
M0 13 (8)   20 (12)   10 (6)   48 (28)  
M1 37 (42) <.0001 21 (24) 0.013 47 (53) <.0001 18 (20) 0.160
Localization         
Colon 25 (20)   22 (18)   33 (27)   38 (31)  
Sigmoid 9 (19)   10 (21)   8 (17)   8 (17)  
Rectum 9 (19) 0.884 9 (10) 0.151 16 (18) 0.180 20 (22) 0.114
Tumor grade c         
G1 & G2 22 (17)   16 (12)   16 (12)   37 (28)  
G3 & G4 25 (21) 0.344 23 (20) 0.102 37 (32) 0.0002 27 (23) 0.372
UICC stage         
I 6 (12)   4 (8)   2 (4)   16 (31)  
II 4 (6)   11 (16)   4 (6)   19 (28)  
III 3 (6)   5 (10)   4 (8)   13 (25)  
IV 37 (42) <.0001 21 (24) 0.049 47 (53) <.0001 18 (20) 0.486
  1. aTumor size was unknown in 1 case.
  2. bNodal status was unknown in 6 cases.
  3. cTumor grade was unknown in 10 cases.