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Table 2 Distribution of LDH and methylation of HLTF , HPP1 and NEUROG1 among clinicopathologic features

From: Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer

Clinical feature

LDH ≥ 250 U/l

HLTF methylation

HPP1 methylation

NEUROG1 methylation

 

n (%)

P

n (%)

P

n (%)

P

n (%)

p

Total positive

50 (19)

 

41 (16)

 

57 (22)

 

66 (25)

 

Age a

        

≤ 65 years

31 (24)

 

18 (14)

 

31 (24)

 

36 (28)

 

> 65 years

19 (15)

0.055

23 (18)

0.410

26 (20)

0.434

30 (23)

0.372

Sex

        

Male

26 (18)

 

22 (15)

 

34 (23)

 

34 (23)

 

Female

24 (21)

0.528

19 (17)

0.744

23 (20)

0.528

32 (28)

0.397

Tumor size a

        

T1

0 (0)

 

2 (13)

 

1 (7)

 

4 (27)

 

T2

9 (19)

 

3 (6)

 

3 (6)

 

12 (25)

 

T3

28 (18)

 

25 (16)

 

32 (21)

 

39 (25)

 

T4

13 (31)

0.062

11 (27)

0.080

20 (48)

<.0001

11 (26)

0.999

Nodal status b

        

N0

14 (10)

 

16 (12)

 

13 (9)

 

37 (27)

 

N1

19 (29)

 

13 (20)

 

23 (35)

 

13 (20)

 

N2

15 (30)

0.0006

11 (22)

0.139

18 (36)

<.0001

16 (32)

0.307

Metastatic disease

        

M0

13 (8)

 

20 (12)

 

10 (6)

 

48 (28)

 

M1

37 (42)

<.0001

21 (24)

0.013

47 (53)

<.0001

18 (20)

0.160

Localization

        

Colon

25 (20)

 

22 (18)

 

33 (27)

 

38 (31)

 

Sigmoid

9 (19)

 

10 (21)

 

8 (17)

 

8 (17)

 

Rectum

9 (19)

0.884

9 (10)

0.151

16 (18)

0.180

20 (22)

0.114

Tumor grade c

        

G1 & G2

22 (17)

 

16 (12)

 

16 (12)

 

37 (28)

 

G3 & G4

25 (21)

0.344

23 (20)

0.102

37 (32)

0.0002

27 (23)

0.372

UICC stage

        

I

6 (12)

 

4 (8)

 

2 (4)

 

16 (31)

 

II

4 (6)

 

11 (16)

 

4 (6)

 

19 (28)

 

III

3 (6)

 

5 (10)

 

4 (8)

 

13 (25)

 

IV

37 (42)

<.0001

21 (24)

0.049

47 (53)

<.0001

18 (20)

0.486

  1. aTumor size was unknown in 1 case.
  2. bNodal status was unknown in 6 cases.
  3. cTumor grade was unknown in 10 cases.