Table 1 Mouse serum toxicity profiles of LCL85 *
| Â | Treatment | ||
|---|---|---|---|
Serum enzyme/protein level | Â | LCL85 (mg/kg body weight) | Â |
|  | Control (n = 2) | 1 (n = 4) | 5 (n = 3) |
ALP (U/L) | 65 ± 7.1 | 67.5 ± 11.6 | 66.7 ± 5.1 |
ALT (U/L) | 20.5 ± 4.9 | 37.8 ± 10.2 | 57.3 ± 24.2 |
GGT (U/L) | <3.0 | <3.0 | <3.0 |
Albumin (g/dl) | 3.2 ± 0.1 | 3.1 ± 0.1 | 3.2 ± 0.2 |
Glucose (mg/dl) | 205 ± 29.7 | 198.5 ± 48.7 | 176.7 ± 23 |
Sodium (mmol/L) | 150.5 ± 0.7 | 152.3 ± 2.2 | 151 ± 3 |
Potassium (mmol/L) | 5.2 ± 0.1 | 6.4 ± 1 | 6.9 ± 0.5 |
Chloride (mmol/L) | 108.5 ± 0.7 | 111 ± 2.6 | 111.7 ± 2.9 |
Bicarbonate (mmol/L) | 16 ± 0 | 14.3 ± 2.2 | 15.7 ± 2.1 |
Anion Gap (mmol/L) | 31 ± 0 | 33.5 ± 4.2 | 30.7 ± 2.5 |
Calcium ((mg/dl) | 10.3 ± 0.1 | 10.2 ± 0.6 | 9.9 ± 0.3 |
Phosphorous (mg/dl) | 8.8 ± 3.7 | 9.2 ± 1.9 | 8.5 ± 0.5 |
Cholesterol (mg/dl) | 74.5 ± 9.2 | 68.8 ± 12.4 | 86 ± 4.6 |
UreaNitrogen (mg/dl) | 24.5 ± 3.5 | 29.3 ± 4 | 26.3 ± 1.5 |
Total Bilirubin (mg/dl) | 0.1 ± 0 | 0.1 ± 0 | 0.1 ± 0 |
Total Protein (g/dl) | 4.5 ± 0.1 | 4.5 ± 0.3 | 4.8 ± 0.2 |