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Figure 10 | BMC Cancer

Figure 10

From: Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression

Figure 10

Ceramide analog and Smac mimetic exhibit additive effects in sensitization of metastatic human colon carcinoma cells to Fas-mediated apoptosis. A & B. SW620 (A) and LS411N (B) cells were cultured in the presence of LCL85 (5 μM), BV6 (5 μM), FasL (250 ng/ml), and the combinations as indicated for approximately 24 h. Cells were stained with Annexin V and PI and analyzed by flow cytometry. Apoptotic cell death for each treatment was indicated at the top right corner of each plot. Percentage of FasL-induced cell death is calculated by the formula: % Annexin V+ and PI+ cells in the presence of FasL- % Annexin V+ and PI+ cells in the absence of FasL, and presented at the right.

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