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Table 3 Association between FAK expression and prognostic factors (categorical variables)

From: Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer

FAK location Parameter Mean FAK score (95% CI) p-value
Vessels Tumour grade   
  1 or 2 156.2 (124.6-187.8)  
  3 200.2 (177.9-222.6) 0.008
  Lymph node involvement   
  Yes 184.7 (157.7-211.7)  
  No 179.6 (152.8-206.5) 0.765
  ER status   
  Positive 161.3 (139.9-184.6)  
  Negative 213.7 (184.7-242.7) 0.005
  PR status   
  Positive 156.8 (131.6-181.9)  
  Negative 212.8 (186.7-238.9) 0.002
  Her2 status   
  Positive 215.8 (181.6-250.0)  
  Negative 169.8 (148.0-191.6) 0.022
  Molecular sub-type   
  Luminal A vs Non-Luminal A 135.4 (107.6-163.2) vs 211.8 (189.0-234.6) <0.001
  Luminal B vs Non-Luminal B 208.0 (169.1-246.9) vs 176.5 (155.5-196.6) 0.130
  Her2 positive vs Non-Her2 235.9 (155.8-316) vs 178.5 (159.5-197.4) 0.121
  TN versus Non-TN 208.4 (176.6-240.1) vs 170.3 (147.6-193.0) 0.043
Tumour cells Tumour grade   
  1 or 2 4.1 (3.6-4.7)  
  3 5.1 (4.8-5.5) 0.001
  Lymph node involvement   
  Yes 5.1 (4.7-5.4)  
  No 4.5 (4.0-5.0) 0.249
  ER status   
  Positive 4.4 (4.0-4.9)  
  Negative 5.2 (4.8-5.6) 0.013
  PR status   
  Positive 4.4 (4.0-4.9)  
  Negative 5.1 (4.7-5.5) 0.048
  Her2 status   
  Positive 5.1 (4.6-5.6)  
  Negative 4.6 (4.2-5.0) 0.215
  Molecular sub-type   
  Luminal A vs Non-Luminal A 4.1 (3.5-4.7) vs 5.2 (4.8-5.5) 0.001
  Luminal B vs Non-Luminal B 5.0 (4.4-5.6) vs 4.7 (4.3-5.0) 0.408
  Her2 positive vs Non-Her2 5.3 (4.5-6.1) vs 4.7 (4.4-5.0) 0.406
  TN versus Non-TN 5.2 (4.7-5.7) vs 4.5 (4.1-4.9) 0.033
  1. Significant findings are in italics (Mann–Whitney test). Abbreviations: CI = confidence interval.