Figure 5

Effect of siRNA knockdown of TKT on glucose uptake and lactate production. A significantly higher amount of glucose was consumed by UM1 (n = 5, p = 0.01) and UM2 (n = 5, p = 0.0003) cells when TKT expression was inhibited by siRNA silencing. Meanwhile, both siTKT-transfected UM1 (n = 5, p = 0.0006) and UM2 cells (n = 5, p = 0.0001) produced significantly higher amount of lactate than the siCTRL-transfected cells.