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Table 4 Correlations of the biomarkers and the neuropsychological tests and self-reported questionnaires

From: Impairment of cognitive functioning during Sunitinib or Sorafenib treatment in cancer patients: a cross sectional study

  Patients VEGFR TKI Patient controls Patients VEGFR TKI Patient controls Patients VEGFR TKI Patient controls Patients VEGFR TKI Patient controls
  CRP ESR LDH VEGF
  r P r P r P r P r P r P r P r P
Neuropsychological tests
Learning & memory -0.427 0.019    -0.410 0.030           
  Working memory                 
  Episodic memory -0.432 0.017               
  Semantic memory                 
Attention & concentration      -0.440 0.019           
  Alertness                 
  Sustained attention                 
Executive functions      -0.376 0.049           
  Response generation                 
  Response inhibition                 
  Mental flexibility                 
  Problem solving                 
Self-reported questionnaires
SLC90-R total score                -0.626 0.004
  Anxiety                -0.526 0.021
  Depression                -0.518 0.023
  Sleep disturbance                 
  Agoraphobia                 
  Somatization                -0.476 0.039
  Cognitive-performance difficulty                -0.540 0.017
  Interpersonal sensitivity and paranoid ideation                -0.638 0.003
  Anger-hostility                -0.729 0.000
CFQ total score                -0.754 0.000
BDI-II total score 0.379 0.039    0.378 0.047    0.464 0.010      -0.622 0.004
CIS20r total score                 
  CIS fatigue                 
  CIS motivation                 
  CIS concentration                -0.466 0.045
  CIS activation                 
  1. Correlations between the biomarkers and the Neuropsychological Tests and Self-report Questionnaires in the VEGFR TKI patients and the patient controls. Only the significant correlations are listed in the table. r = Pearson correlation coefficient.