| |
Patients VEGFR TKI
|
Patient controls
|
Healthy controls
|
|---|
| |
Mean
|
SD
|
Mean
|
SD
|
Mean
|
SD
|
|---|
|
SCL-90-R
| | | | | | |
|
Anxiety
|
13.07**
|
3.10
|
12.75*
|
3.06
|
11.10
|
1.71
|
|
Depression
|
23.87***
|
6.31
|
22.55**
|
5.32
|
18.20
|
2.68
|
|
Sleep disturbance
|
4.93
|
2.57
|
5.00
|
2.03
|
4.10
|
1.40
|
|
Agoraphobia
|
7.90
|
2.01
|
8.10
|
2.20
|
7.40
|
0.77
|
|
Somatization
|
19.23***
|
5.73
|
17.40*
|
6.07
|
14.17
|
3.18
|
|
Cognitive-performance difficulty
|
14.77**
|
4.68
|
14.75**
|
4.82
|
11.43
|
2.13
|
|
Interpersonal sensitivity and paranoid ideation
|
20.90
|
3.63
|
22.50
|
5.69
|
20.87
|
3.15
|
|
Anger-hostility
|
6.90
|
1.27
|
6.90
|
1.12
|
6.43
|
0.86
|
|
Total score
|
123.10***
|
24.13
|
121.80**
|
26.81
|
103.67
|
11.88
|
|
CFQ
| | | | | | |
|
Total score
|
93.37
|
13.20
|
89.55
|
10.13
|
91.80
|
9.64
|
|
BDI-II
| | | | | | |
|
Total score
|
9.87***
|
5.76
|
8.25**
|
5.78
|
3.60
|
2.98
|
|
CIS20r
| | | | | | |
|
Total score
|
67.67***
|
26.75
|
61.05*
|
21.11
|
46.60
|
16.24
|
- Self-reported psychological well-being, subjective cognitive complaints, depressive symptoms and level of fatigue (mean + SD) for the patients using VEGFR TKI, the patient controls and the healthy controls. Post-hoc t-tests, patient groups compared to healthy controls: *P < 0.05, **P < 0.01, ***P < 0.001. Abbreviations:
SCL-90-R Symptom Checklist-Revised, CFQ Cognitive Failures Questionnaire, BDI-II Beck Depression Inventory-Second Edition, CIS-20-R Checklist Individual Strength-Revised.
