Skip to main content

Table 2 Cognitive subdomain scores and raw neuropsychological test scores

From: Impairment of cognitive functioning during Sunitinib or Sorafenib treatment in cancer patients: a cross sectional study

  Patients VEGFR TKI Patient controls Healthy controls
  Mean SD Mean SD Mean SD
Learning & memory       
Working memory -0.26 0.93 0.11 0.95 0.19 0.79
  Digit span backwards WAIS-III 5.67 1.77 6.40 1.98 6.37 1.75
  Letter-number sequencing WAIS-III 9.47 2.27 10.15 2.08 10.50 1.59
Episodic memory -0.31*** 0.89 -0.11* 0.74 0.38 0.56
  RAVLT total score 33.70 8.01 37.55 8.25 39.77 5.76
  RAVLT delayed recall 5.87 2.57 7.00 2.32 7.37 2.50
  RAVLT delayed recognition 26.33 3.02 27.70 1.59 28.03 1.45
  RBMT story (Immediate Recall) 9.62 2.75 9.42 3.14 11.75 2.51
  RBMT story (Delayed Recall) 8.43 3.51 7.85 3.30 10.38 2.56
Semantic memory -0.36*** 0.97 -0.26** 0.89 0.53 0.88
  Semantic fluency (Animal) 22.47 5.49 22.95 4.39 26.73 5.22
  Semantic fluency (Profession) 16.30 4.65 16.80 5.19 20.70 4.21
Attention & concentration       
Alertness -0.17 0.88 0.17 0.68 0.06 0.59
  Digit span forwards WAIS-III 8.23 2.05 9.20 1.94 8.47 1.28
  TAP 2.1 alertnessa 256.28 51.96 248.40 35.52 240.75 27.45
Sustained attention -0.22 0.93 0.18 1.16 0.10 0.94
  d2 test 138.63 30.93 151.60 38.33 149.03 31.25
Executive functions       
Response generation -0.26* 0.91 -0.13 1.23 0.35 0.83
  Letter fluency (COWAT) 32.97 9.28 34.25 12.58 39.17 8.46
Response inhibition -0.04 1.05 0.01 1.05 0.04 0.95
  Stroop color word test (Interference)a 0.70 0.30 0.73 0.47 0.65 0.21
Mental flexibility -0.29 0.98 0.11 1.13 0.22 0.88
  TAP flexibility (Alternation)a 900.37 353.23 824.40 405.37 732.03 177.52
Problem solving -0.19* 0.88 -0.18* 0.85 0.31 0.74
  Raven APM (Set I) 8.00 2.23 8.10 2.02 9.50 1.93
  Brixton spatial anticipation Test 36.97 6.06 36.90 6.31 38.83 5.43
  1. Cognitive subdomain scores (standardized Z-scores, mean + SD) and raw neuropsychological test scores (mean + SD) for the patients using VEGFR TKI, the patient controls and the healthy controls. Higher scores indicate a better performance except where noted. Post-hoc t-tests, patient groups compared to healthy controls, for the cognitive subdomain scores: *P < 0.05, **P < 0.01, ***P < 0.001. aHigher scores reflect a worse performance. Abbreviations: RAVLT Rey Auditory Verbal Learning Test, RBMT Rivermead Behavioural Memory Test, WAIS-III Wechsler Adult Intelligence Scale–Third Edition, TAP Test for Attentional Processing, Raven APM Raven Advanced Progressive Matrices.