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Table 5 Publications on acute toxicity of radiotherapy of the prostate bed with or without pelvic irradiation

From: Helical intensity-modulated Radiotherapy of the Pelvic Lymph Nodes with Integrated Boost to the Prostate Bed - Initial Results of the PLATIN 3 Trial

 

Acute grade 1

Acute grade 2

Acute grade 3

Acute grade 4

  

GI

GU

GI

GU

GI

GU

GI

GU

Bellavita et al. [13]

3D-CRT prostate bed 66.6 Gy

48.9% (G1/2)

-

-

-

1.1%

-

0%

0%

Current trial

IMRT WPRT 51 Gy + boost prostate bed 68 Gy

67.5%

22.5%

22.5%

22.5%

0%

0%

0%

0%

Alongi et al.[14]

IMRT WPRT 50.6 Gy + boost prostate bed 70–72.5 Gy

-

-

3.3%

6.6%

0%

0%

0%

0%

Deville et al.[15]

IMRT WPRT 45 Gy Gy + boost prostate bed 70.2 Gy

31%

67%

61%

22%

0%

0%

0%

0%

Alongi et al.[14]

3D-CRT WPRT 50.1 Gy + boost prostate bed 72.1 Gy

-

-

8.6%

12.3%

0%

0%

0%

0%

Aizer et al.[16]

3D-CRT WPRT 45 Gy + IMRT boost prostate 75.6 Gy

75%

44.1%

17.6%

33.8%

1.5%

10.3%

0%

0%

Roach et al.[4]

3D-CRT WPRT 45 Gy + boost prostate 70.2 Gy

-

-

-

-

2.6% (G3/4)

3.9% (G3/4)

0%

0%

Liu et al.[17]

2D WPRT 45 Gy + boost prostate 72 Gy

12.2%

10.9%

1.3%

3.8%

0.6%

0.6%

0%

-

  1. Published data on acute toxicity of adjuvant 3D conformal radiotherapy (3D-CRT) of the prostate bed (regular print), adjuvant intensity-modulated radiotherapy (IMRT) of the whole pelvis (WPRT) with a boost to the prostate bed (bold print) and definitive or adjuvant 3D-CRT WPRT with a boost to the prostate or prostate bed (italic print). (GI = gastrointestinal, GU = genitourinary).