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Table 2 Acute and late gastrointestinal toxicity

From: Helical intensity-modulated Radiotherapy of the Pelvic Lymph Nodes with Integrated Boost to the Prostate Bed - Initial Results of the PLATIN 3 Trial

Diarrhea Grade 1 Grade 2 Grade 3 Grade 4
End of RT 28.2% 2.6% - -
13 weeks 7.9% - - -
6 months - 2.7% - -
12 months 2.7% - - -
18 months - - - -
24 months - - - -
Enteritis Grade 1 Grade 2 Grade 3 Grade 4
End of RT 15.4% - - -
13 weeks - 7.9% - -
6 months - 5.4% - -
12 months - - - -
18 months 31.% - - -
24 months - 4.5% - -
Proctitis Grade 1 Grade 2 Grade 3 Grade 4
End of RT 17.9% 12.8% - -
13 weeks 10.5% - - -
6 months 2.7% 2.7% - -
12 months - - - -
18 months - - 3.1% -
24 months - - - -
  1. Diarrhea: CTC AE grade 1 = increase < 4 stools per day over baseline; grade 2 = increase 4-6 stools per day; grade 3 = increase ≥ 7 stools per day or incontinence or hospitalisation or limiting self care ADL; grade 4 = life-threatening consequences, urgent intervention indicated.
  2. Enteritis: CTC AE grade 1 = asymptomatic; grade 2 = abdominal pain, mucus or blood in stool; grade 3 = severe or persistent abdominal pain, fever, ileus, peritoneal signs; grade 4 = life-threatening consequences, urgent intervention indicated.
  3. Proctitis: CTC AE grade 1 = rectal discomfort, intervention not indicated; grade 2 = symptoms (e.g. rectal discomfort, passing blood or mucus), medical intervention, limiting instrumental ADL; grade 3 = severe symptoms, fecal urgency or stool incontinence, limiting self care ADL; grade 4 = life-threatening consequences, urgent intervention indicated.