Table 1 Immunohistochemical analysis of MEKK3 protein in esophageal tissues and relationship with clinicopathological parameters
Clinicopathological features | Total cases (N) | Cytoplasmic/nuclear positivity n (%) | P-value | OR (95% CI) |
|---|---|---|---|---|
Normal | 47 | 10 (21) | ||
Dysplasia | 61 | 34 (55.7) | <0.001 | 4.6 (1.9-11.0) |
ESCC | 93 | 63 (67.7) | 0.001 | 7.77 (3.41-17.7) |
Age (years) | ||||
<54 | 43 | 30 (69.8) | 0.825 | 0.84 (0.35-2.01) |
> = 54 | 50 | 33 (66) | ||
Gender | ||||
Male | 62 | 40 (64.5) | 0.481 | 1.58 (0.60-4.12) |
Female | 31 | 23 (74.2) | ||
Tumor stage | ||||
(T1 + T2) | 10 | 6 (60.0) | 0.722 | 1.46 (0.38-5.62) |
(T3 + T4) | 83 | 57 (68.7) | ||
Nodal status | ||||
N0 | 27 | 19 (70.4) | 0.81 | 0.84 (0.31-2.22) |
N1 | 66 | 44 (66.7) | ||
Histopathology | ||||
WDSCC | 30 | 20 (66.7) | 0.61 | 0.6 (0.20-1.87) |
MDSCC | 48 | 33 (68.7) | ||
PDSCC | 15 | 10 (66.7) |