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Figure 2 | BMC Cancer

Figure 2

From: Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells

Figure 2

Analysis of the human AKT1 locus and known transcripts to identify a sequence that is orthologous to the mouse Akt1m . (A) Diagram of the human AKT1 promoter region with transcriptional start sites and the location of 5′ untranslated exons of five currently known AKT1 transcripts using the UCSC Genome Browser. The red arrow indicates an exon that is not associated with any of the known transcripts in GenBank. (B) Graphical illustration of all transcript variants of the human AKT1 that are present in GenBank. (C) Genomic sequence comparison of the previously identified murine Akt1m exon with a putative human AKT1m ortholog according to the UCSC Genome Browser. Conserved nucleotides are highlighted in yellow (40% sequence similarity).

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