Figure 9
Expression of VM signal-related proteins PI3-K, MMP-2, MM1-MMP and Ln-5γ2 of GBC-CD xenografts in vivo (indirect immunofluorescence method, original magnification, ×400). The positive expression site of these proteins presented bright yellow-green fluorescent staining reactant was all in cytoplast. Expression of PI3-K, MMP-2, MM1-MMP and Ln-5γ2 proteins in control group was all upregulated markedly. However, expression of these proteins in TIMP-2 group and NCTD group was significantly downregulated (*P < 0.001, vs. control group). But, no difference on expression of these proteins was observed between NCTD group and TIMP-2 group.