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Figure 7 | BMC Cancer

Figure 7

From: Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5γ2 signaling pathway

Figure 7

Expression of MMP-2, MT1-MMP proteins from sections [(A), SABC method, original magnification, ×200)] and supernates [(B), ELISA] of the 3-D cultures of GBC-SD cells in vitro . (A) The positive expression site of MMP-2 and MT1-MMP proteins presented yellow-brown reactant was in cytoplast. Expression of MMP-2 and MT1-MMP proteins in TIMP-2 group and NCTD group was significantly lower than that of control group (all *P < 0.001). (B) Expression of MMP-2 and MT1-MMP proteins from supernates of 3-D culture samples in control group increased significantly as time prolonged, when compared with TIMP-2 group or NCTD group (all *P < 0.001).

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