Preoperative chemoradiotherapy in rectal cancer induces changes in the expression of nuclear β-catenin: prognostic significance

Table 5 Multivariant Cox regression analysis

Explanatory variable	Univariant	P	Multivariant	P
	HR (95% CI)		HR (95% CI)
Increase in β-catenin				0.06
Decrease vs. increase	0.14 (0.02-0.9)	0.02	0.13 ( 0.01-1.4)	0.06
T stage				0.02
T4 vs. T2-T3	1.7 (0.7-4.3)	0.2	4 (1.2-13.4)	0.02
N stage				0.6
N- vs. N+	0.4 (0.18.1.1)	0.07	0.7 (0.2-2.3)	0.6
TGR*				0.4
3-5 vs. 1-2	3.6 (1.2-10.7)	0.01	0.5 (0.1-2.6)	0.4
pN ††				0.01
pN - vs. pN+	0.3 (0.14-0.77)	0.007	0.2 (0.06-0.69)

*TGR: Tumor grade regression. pN: pathological lymphatic metastases. †† pN: pathological lymphatic metastases.

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