Table 3 Distribution of the R497K and (CA)n genotypes according to prognostic variables
Prognostic variables | R497K | (CA)n | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Arg/Arg | Arg/Lys | Lys/Lys | Short/short | Short/long | Long/long | |||||
Total | n = 308 | n = 176 | n = 21 | Total | n = 108 | n = 230 | n = 139 | |||
n | % | % | % | P | n | % | % | % | P | |
Age | ||||||||||
> 35 years-old | 493 | 61.7 | 34.1 | 4.3 | 0.06 | 466 | 22.7 | 48.5 | 28.8 | 0.48 |
≤ 35 years-old | 112 | 33.3 | 66.7 | 0.0 | 11 | 18.2 | 36.4 | 45.5 | ||
Familial history | ||||||||||
No | 400 | 60.0 | 36.0 | 4.0 | 0.99 | 376 | 21,5 | 49,7 | 28,7 | 0.38 |
Yes | 56 | 60.7 | 35.7 | 3.6 | 53 | 26,4 | 39,6 | 34.0 | ||
Histological type | ||||||||||
in situ | 35 | 62.9 | 34.3 | 2.9 | 0.91 | 33 | 15.2 | 48.5 | 36.4 | 0.44 |
Invasive | 459 | 61.0 | 34.6 | 4.4 | 434 | 23.3 | 48.6 | 28.1 | ||
Tumor grade | ||||||||||
Grade 1 | 60 | 56.7 | 40.0 | 3.3 | 0.64 | 58 | 25.9 | 46.6 | 27.6 | 0.74 |
Grade 2 or 3 | 413 | 61.3 | 34.1 | 4.6 | 389 | 21.3 | 48.8 | 29.8 | ||
Tumor size | ||||||||||
pT ≤ 2 cm | 224 | 59.4 | 36.6 | 4.0 | 0.65 | 214 | 22.9 | 45.3 | 31.8 | 0.24 |
pT > 2 cm | 233 | 62.7 | 32.6 | 4.7 | 218 | 23.4 | 51.8 | 29.8 | ||
Lymph node status | ||||||||||
pN0 or pN1 | 429 | 58.0 | 37.3 | 4.7 | 0.005 | 405 | 22.7 | 47.2 | 30.1 | 0.47 |
pN2 or pN3 | 76 | 77.6 | 21.1 | 1.3 | 72 | 22.2 | 54.2 | 23.6 | ||
ER status | ||||||||||
Negative | 76 | 68.4 | 27.6 | 3.9 | 0.38 | 72 | 26.4 | 51.4 | 22.2 | 0.29 |
Positive | 411 | 60.1 | 35.5 | 4.4 | 387 | 21.2 | 47.8 | 31.0 | ||
PR status | ||||||||||
Negative | 133 | 63.2 | 32.3 | 4.5 | 0.87 | 128 | 28.1 | 50.0 | 21.9 | 0.031 |
Positive | 353 | 60.9 | 34.8 | 4.2 | 330 | 19.4 | 47.9 | 32.7 | ||
HER2 status | ||||||||||
Negative | 376 | 59.3 | 35.6 | 5.1 | 0.13 | 356 | 21.9 | 50.0 | 28.1 | 0.30 |
Positive | 72 | 65.3 | 34.7 | 0.0 | 67 | 20.9 | 41.8 | 37.3 | ||
Biological classification | ||||||||||
Luminal A | 291 | 58.8 | 36.4 | 4.8 | 0.68 | 275 | 20.0 | 49.8 | 30.2 | 0.35 |
Luminal B | 88 | 60.2 | 36.4 | 3.4 | 83 | 21.7 | 43.4 | 34.9 | ||
HER2 like | 26 | 73.1 | 26.9 | 0.0 | 24 | 37.5 | 41.7 | 20.8 | ||
Triple negative | 44 | 63.6 | 29.5 | 6.8 | 42 | 23.8 | 54.8 | 21.4 | ||