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Table 2 Characterization of a subcohort used for tumoral RNA analyses, and comparison with the complete cohort

From: Epidermal growth factor receptor gene polymorphisms are associated with prognostic features of breast cancer

  Complete cohort Tumor subcohort  
Individual variables Total n = 508 Total n = 129 P
  n % n %  
Age      
  > 35 years-old 496 97.6 125 96.9 0.63
 ≤ 35 years-old 12 2.4 4 3.1  
Family history      
 No 400 87.7 85 85.9 0.61
 Yes 56 12.3 14 14.1  
Histological type      
in situ 35 7.0 2 1.6 0.018
 Invasive 462 93.0 127 98.4  
Tumor grade      
 Grade 1 60 12.6 10 7.8 0.14
 Grade 2 or 3 416 87.4 117 90.7  
Tumor size      
 pT ≤ 2 cm 226 49.1 42 33.1 0.001
 pT > 2 cm 234 50.9 85 66.9  
Lymph node status      
 pN0 or pN1 432 85.0 99 76.7 0.024
 pN2 or pN3 76 15.0 30 23.3  
ER/PR status      
 Negative (both) 76 15.5 27 20.9 0.14
 Positive (either) 414 84.5 102 79.1  
HER2 status      
 Negative 378 83.8 102 81.0 0.45
 Positive 73 16.2 24 19.0  
Biological classification      
 Non triple negative 440 90.9 112 86.8 0.17
 Triple negative 44 9.1 17 13.2  
EGFR genotypes      
R497K      
Arg/Arg 308 61.0 82 64.1 0.380
Arg/Lys 176 34.9 38 29.7
Lys/Lys 21 4.2 8 6.3  
(CA)n      
Short/Short 108 22.6 30 23.6 0.358
Short/Long 230 48.2 68 53.5  
Long/Long 139 29.1 29 22.8  
  1. Abbreviations: ER Estrogen receptor, PR Progesterone receptor, HER2 Human Epidermal groth factor Receptor 2. Statistically significant differences are presented in bold characters.