Figure 4From: Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study Example TEM micrographs. (a) Histologically normal rectal cell nuclei from control patients and those harboring a pre-cancerous adenoma elsewhere in the colon, representing field CRC. Scale bars correspond to 500Â nm. (b) Histologically normal colonic cell nuclei from control rats and those treated with azoxymethane for 10Â weeks (premalignant time point), representing early CRC. Scale bars correspond to 250Â nm.Back to article page