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Table 4 Combinations of categories of alcohol consumption and cigarette smoking and risk (multivariable a adjusted incidence RRs) of subtypes of head-neck cancer; Netherlands Cohort Study (NLCS), 1986 - 2003

From: Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study

  Head-neck cancer cases
  Overall Subtypes      
       OCCb OHPCb LCb
  Alcohol consumption (grams ethanol/day) Alcohol consumptionc Alcohol consumptionc Alcohol consumptionc
  0 >0 to <5 5 to <15 15 to <30 ≥30 0-15 >15 0-15 >15 0-15 >15
Frequency of cigarette smoking ( N /day)
Never smokers            
Cases/person time at riskd 10/8959 13/9729 7/4245 11/1499 3/619 21/22933 8/2118 3/22933 3/2118 6/22933 3/2118
RR 1 (ref) 1.20 1.23 5.53 2.97 1 (ref) 4.16 1 (ref) 10.18 1 (ref) 3.05
95% CI   0.52 – 2.75 0.46 – 3.29 2.27 – 13.49 0.78 – 11.40   1.82 – 9.52   2.03 – 51.06   0.72 – 12.92
>0 to <20            
Cases/person time at risk 21/4194 25/6534 37/7061 40/4814 32/2184 20/17789 18/6998 18/17789 12/6998 44/17789 41/6998
RR 1.89 1.56 2.04 2.63 3.81 0.76 1.55 4.02 5.63 2.66 4.19
95% CI 0.83 – 4.34 0.71 – 3.41 0.95 – 4.40 1.22 – 5.67 1.71 – 8.51 0.34 – 1.71 0.66 – 3.62 1.07 – 15.14 1.44 – 22.00 1.03 – 6.86 1.60 – 11.02
≥20            
Cases/person time at risk 18/2102 29/2745 28/3162 41/3648 80/2856 7/8010 36/6504 16/8010 31/6504 52/8010 53/6504
RR 2.78 3.88 2.85 3.32 8.28 0.58 3.54 7.26 16.12 5.42 5.54
95% CI 1.18 – 6.54 1.77 – 8.49 1.28 – 6.34 1.52 – 7.25 3.98 – 17.22 0.21 – 1.58 1.66 – 7.52 1.86 – 28.44 4.31 – 60.27 2.10 – 13.98 2.15 – 14.27
P for interactione      0.03   0.10   0.09   0.19
  1. aAdjusted for age, sex, current cigarette smoking, and duration of cigarette smoking (years; continuous; centered).
  2. bOCC: oral cavity cancer; OHPC: oro-/hypopharyngeal cancer; LC: laryngeal cancer.
  3. cFor the categorical interaction analyses in HNC-subtypes, it was necessary to aggregate categories of alcohol consumption (grams ethanol/day) in order to obtain sufficient numbers in strata.
  4. dPerson time at risk in years.
  5. e P Value for interaction between categories of alcohol consumption and cigarette smoking, based on cross-product terms in the Cox proportional hazards model and Wald test.