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Figure 3 | BMC Cancer

Figure 3

From: Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells

Figure 3

γH2AX and RAD51 foci formation in HEC-6 cells after olaparib treatment. (A) Immunofluorescence images of PTEN-/+ HEC6 cell lines: Hoechst-stained nuclei (blue), γ-H2AX (red), and RAD51 (green) after olaparib exposure (10 μM) for 24 h. (B) The number of γ-H2AX and RAD51 foci following exposure to olaparib (10 μM) was counted in the HEC-6 cell lines. The experiments were repeated 3 times, and each value is shown as the mean of 3 experiments ± SD. (C) Time course expression of cleaved PARP and PTEN in PTEN-/+ HEC-6 cell lines. Proteins were extracted after 24 h of olaparib (10 μmol/L) exposure.

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