Effect of intratumoral injection with Saline, Virus_Scramble, or Virus_CCND1 on proliferation and apoptosis in tumors. In H&E staining, tumor tissues of Virus_CCND1 had decreased mitotic figure compared to that of Saline and Virus_Scramble, respectively. In the TUNEL assay, the number of apoptotic cells of Virus_CCND1 were increased compared to the number of Saline and Virus_Scramble (A and B). Original magnification, 400×. The data presented are the mean ± SEM. ***P < 0.001 versus Saline and ###P < 0.001 versus Virus_Scramble.