Figure 1From: Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR) Scheme of the METEOR trial. Patients meeting the inclusion criteria will be 1:1 randomized to 24Â weeks of letrozole plus metformin or letrozole plus placebo. Core needle biopsies will be recommended after 4Â weeks of treatment. Surgery will be performed within 2Â weeks after the end of the 24Â week treatment period.Back to article page