Table 3 Non-hematologic adverse events (AEs) and hematologic laboratory abnormalities (N = 60)
AE or laboratory abnormality | n (%) | |||
|---|---|---|---|---|
Grade 1/2 | Grade 3 | Grade 4 | Any grade | |
Non-hematologic AEs of any cause occurring in ≥ 15% of patients | ||||
 Fatigue/asthenia | 33 (55) | 12 (20) | 0 | 45 (75) |
 Diarrhea | 33 (55) | 3 (5) | 0 | 36 (60) |
 Stomatitis, oral discomfort, and related oral syndromes | 29 (48) | 3 (5) | 0 | 32 (53) |
 Dysgeusia | 27 (45) | 0 | 0 | 27 (45) |
 Hypertension | 18 (30) | 8 (13) | 0 | 26 (43) |
 Skin and subcutaneous tissue disorders | 25 (42) | 0 | 0 | 25 (42) |
 Vomiting | 19 (32) | 2 (3) | 0 | 21 (35) |
 Dyspepsia | 20 (33) | 0 | 0 | 20 (33) |
 Epistaxis | 18 (30) | 2 (3) | 0 | 20 (33) |
 Nausea | 20 (33) | 0 | 0 | 20 (33) |
 Headache | 17 (28) | 2 (3) | 0 | 19 (32) |
 Decreased appetite | 14 (23) | 4 (7) | 0 | 18 (30) |
 Dry skin | 14 (23) | 1 (2) | 0 | 15 (25) |
 Ejection fraction decreased | 10 (17) | 3 (5) | 1 (2) | 14 (23) |
 Abdominal pain | 11 (18) | 0 | 0 | 11 (18) |
 Hand–foot syndrome and related disorders | 8 (13) | 3 (5) | 0 | 11 (18) |
 Pyrexia | 11 (18) | 0 | 0 | 11 (18) |
 Weight decreased | 11 (18) | 0 | 0 | 11 (18) |
 Constipation | 10 (17) | 0 | 0 | 10 (17) |
 Left ventricular dysfunction | 8 (13) | 2 (3) | 0 | 10 (17) |
 Insomnia | 8 (13) | 1 (2) | 0 | 9 (15) |
 Dyspnea | 8 (13) | 1 (2) | 0 | 9 (15) |
Hematologic laboratory abnormalities | ||||
 Leukopenia | 46 (77) | 4 (7) | 1 (2) | 51 (85) |
 Anemia | 46 (77) | 2 (3) | 0 | 48 (80) |
 Neutropenia | 36 (60) | 9 (15) | 1 (2) | 46 (77) |
 Lymphopenia | 36 (60) | 6 (10) | 1 (2) | 43 (72) |
 Thrombocytopenia | 34 (57) | 6 (10) | 3 (5) | 43 (72) |