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Figure 3 | BMC Cancer

Figure 3

From: Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer

Figure 3

Expression of predicted NKX3.1 target genes in response to NKX3.1 inhibition. (A) Depletion of NKX3.1 results in increases in mRNA levels of wild type TMPRSS2, TMPRSS2-ERG fusion (T2-ERG), HDAC9, RUNX1, NFкB and JARID. In contrast, robust reduction of CFTR levels is apparent in response to NKX3.1 inhibition. (B) Rescue of ERG and its downstream function by NKX3.1 inhibition (NKX3.1 siRNA) is shown by nuclear localization of ERG (upper panel), sharp increases in ERG protein levels (lower panel), and by the depletion of the ERG-downstream target prostein (SLC45A3). Schematic depiction of the negative regulatory role of NKX3.1 in the context of TMPRSS2-ERG (T2-ERG) gene fusion (inset).

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