Figure 1
From: Increased paired box transcription factor 8 has a survival function in Glioma
PAX8 immunostaining in gliomas. Representative examples of PAX8-positive and PAX8-negative immunostaining are illustrated (A-D). Tissue sections were subjected to immunohistochemical stainings using an antibody raised against PAX8 (rabbit polyclonal, Cell Marque) and counterstained with hematoxylin. PAX8-positive cells were detected by light microscopy. PAX8-positive cells were detected in glioblastoma (A) and meningioma (B). (C) A PAX8-negative glioblastoma was observed at low (left) and high (right) magnification. (D) Normal brain tissue adjacent to glioma cells was PAX8-negative except between the cerebellar molecular and nuclear layers. Examples of PAX8-positive cells are highlighted with black arrows (tumours cells) and with red arrows (non-malignant cells).