Table 2 Stratified analysis of the pooled hazard ratio (HR) for the associations of high Ki-67 expression with overall survival (OS) of lymphoma
|  |   Heterogeneity | |||||
|---|---|---|---|---|---|---|
Stratified analysis | Number of studies | Number of patients | Pooled HR(95% CI) | P value | I2(%) | P value |
Publication era | Â | Â | Â | Â | Â | Â |
Published in 21st | 20 | 3488 | 1.689(1.386-2.057) | 0.000 | 72.7% | 0.000 |
Published in 20th | 4 | 382 | 1.671(1.41-1.98) | 0.000 | 88,2% | 0.000 |
Study location | Â | Â | Â | Â | Â | Â |
Europe and America | 19 | 3443 | 1.749(1.447-2.114) | 0.000 | 84.9% | 0.000 |
Asia | 4 | 377 | 1.694(1.089-2.635) | 0.019 | 44.1% | 0.147 |
Number of patients | Â | Â | Â | Â | Â | Â |
≥100 | 12 | 2394 | 1.35(1.144-1.593) | 0.00 | 80.8% | 0.000 |
<100 | 12 | 1476 | 2.663(1.923-3.687) | 0.000 | 49.3% | 0.027 |
High expression threshold | Â | Â | Â | Â | Â | Â |
≥50% | 14 | 2332 | 1.906(1.429-2.543) | 0.000 | 73.4% | 0.000 |
<50% | 9 | 1098 | 1.722(1.238-2.395) | 0.001 | 76.2% | 0.000 |
Quality score | Â | Â | Â | Â | Â | Â |
≥7 | 11 | 2582 | 1.584(1.188-2.112) | 0.002 | 70.9% | 0.000 |
<7 | 13 | 988 | 1.815(1.451-2.271) | 0.000 | 85.9% | 0.000 |
Study design | Â | Â | Â | Â | Â | Â |
P | 9 | 2550 | 1.336(1.001-1.782) | 0.049 | 70.8% | 0.000 |
R | 15 | 1320 | 2.144(1.628-2.824) | 0.000 | 85.8% | 0.000 |