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Table 2 Stratified analysis of the pooled hazard ratio (HR) for the associations of high Ki-67 expression with overall survival (OS) of lymphoma

From: Ki-67 is a valuable prognostic predictor of lymphoma but its utility varies in lymphoma subtypes: evidence from a systematic meta-analysis

    Heterogeneity
Stratified analysis Number of studies Number of patients Pooled HR(95% CI) P value I2(%) P value
Publication era       
Published in 21st 20 3488 1.689(1.386-2.057) 0.000 72.7% 0.000
Published in 20th 4 382 1.671(1.41-1.98) 0.000 88,2% 0.000
Study location       
Europe and America 19 3443 1.749(1.447-2.114) 0.000 84.9% 0.000
Asia 4 377 1.694(1.089-2.635) 0.019 44.1% 0.147
Number of patients       
≥100 12 2394 1.35(1.144-1.593) 0.00 80.8% 0.000
<100 12 1476 2.663(1.923-3.687) 0.000 49.3% 0.027
High expression threshold       
≥50% 14 2332 1.906(1.429-2.543) 0.000 73.4% 0.000
<50% 9 1098 1.722(1.238-2.395) 0.001 76.2% 0.000
Quality score       
≥7 11 2582 1.584(1.188-2.112) 0.002 70.9% 0.000
<7 13 988 1.815(1.451-2.271) 0.000 85.9% 0.000
Study design       
P 9 2550 1.336(1.001-1.782) 0.049 70.8% 0.000
R 15 1320 2.144(1.628-2.824) 0.000 85.8% 0.000