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Table 2 Relationship between MGMT expression/activity and MGMT promoter methylation in GSC lines

From: Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide

GSC MGMT/Tubulin MGMT activity (fmol/mg) CpG 73 CpG 75 CpG 79 CpG 80 CpG 83 CpG 86 CpG 87 CpG 89 CpG mediana
#62 0.1 40 83.3 83.3 100 100 100 100 100 100 100
#144 0.01 1 50 100 100 100 100 100 83.3 83.3 83.3
#28 0.69 152 70 70 70 60 70 50 80 60 60
#23 0.01 1 0 100 16.7 100 66.7 100 100 50 33.3
#1 0.45 139 70 70 50 60 40 30 60 50 30
#74 0.04 81 12.5 25 0 25 0 12.5 62.5 37.5 12.5
#83 1.38 247 0 0 0 0 0 0 0 0 0
#30 1.67 200 0 0 0 0 0 0 0 0 0
#148 1.72 210 0 0 0 0 0 0 14.3 0 0
#61 1.43 240 0 0 0 0 0 0 0 0 0
  1. aMedian value of DNA methylation of all 27 CpGs analyzed by bisulfite sequencing.