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Table 2 Relationship between MGMT expression/activity and MGMT promoter methylation in GSC lines

From: Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide

GSC

MGMT/Tubulin

MGMT activity (fmol/mg)

CpG 73

CpG 75

CpG 79

CpG 80

CpG 83

CpG 86

CpG 87

CpG 89

CpG mediana

#62

0.1

40

83.3

83.3

100

100

100

100

100

100

100

#144

0.01

1

50

100

100

100

100

100

83.3

83.3

83.3

#28

0.69

152

70

70

70

60

70

50

80

60

60

#23

0.01

1

0

100

16.7

100

66.7

100

100

50

33.3

#1

0.45

139

70

70

50

60

40

30

60

50

30

#74

0.04

81

12.5

25

0

25

0

12.5

62.5

37.5

12.5

#83

1.38

247

0

0

0

0

0

0

0

0

0

#30

1.67

200

0

0

0

0

0

0

0

0

0

#148

1.72

210

0

0

0

0

0

0

14.3

0

0

#61

1.43

240

0

0

0

0

0

0

0

0

0

  1. aMedian value of DNA methylation of all 27 CpGs analyzed by bisulfite sequencing.