Figure 2From: Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide Sensitivity of GSC lines to TMZ as single agent. Panel A. Chemosensitivity of GSC and GBM cell lines. Tumor growth was evaluated 7 days after drug exposure. Data were plotted in 4 different graphs which gather GSC lines with TMZ IC50s >300 μM (#23, #83, #1, #61, #30), with TMZ IC50s comprised between 200 and 300 μM (#148, #62), with TMZ IC50 < 100 μM (#74, #28, #144) and the two GBM cell lines (SJGBM-2, U87). The results are expressed as survival fraction and are the mean (± SD) of three independent experiments. Panel B. Doubling times of GSC and GBM cell lines. Data are the mean (±SD) of three independent determinations.Back to article page