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Table 5 Correlations between IL-6, IL-8, CXCR-2, SOCS-3 and VEGF H-score and microvascular characteristics (Results of Spearman correlation coefficient)

From: The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma

  MVD TVA Major axis length Minor axis length Area Perimeter Feret diameter Compactness Shape factor
IL-6 NS NS NS NS NS NS NS NS NS
IL-8 R = -0.1873, p = 0.0432** NS NS NS NS NS NS NS NS
CXCR2 NS NS R = -0.1884, p = 0.0419 R = -0.1804, p = 0.0516 R = -0.1541, p = 0.0972 R = -0.1818, p = 0.0497 R = -0.1541, p = 0.0972 R = -0.1756, p = 0.0582 R = 0.1758, p = 0.0579
SOCS-3 NS NS NS NS NS NS NS R = -0.1686, p = 0.0693 R = 0.1684, p = 0.0695*
pSTAT3 NS NS NS NS NS NS NS NS NS
VEGF NS R = 0.2166, p = 0.0230 NS NS R = 0.1967, p = 0.0394 NS R = 0.1967, p = 0.0394 NS NS
  1. NS: not significant.
  2. *When analysis was performed on a categorical basis SOCS-3 H-score was significantly correlated with shape factor (Mann Whitney U test, p = 0.0286).
  3. **This relationship failed to attain statistical significance in a multivariate model including MVD and IL-8 H-score along with histological grade, the latter emerging as a confounder in the correlation between these two molecules.