The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma

BMC Cancer

Table 5 Correlations between IL-6, IL-8, CXCR-2, SOCS-3 and VEGF H-score and microvascular characteristics (Results of Spearman correlation coefficient)

	MVD	TVA	Major axis length	Minor axis length	Area	Perimeter	Feret diameter	Compactness	Shape factor
IL-6	NS	NS	NS	NS	NS	NS	NS	NS	NS
IL-8	R = -0.1873, p = 0.0432**	NS	NS	NS	NS	NS	NS	NS	NS
CXCR2	NS	NS	R = -0.1884, p = 0.0419	R = -0.1804, p = 0.0516	R = -0.1541, p = 0.0972	R = -0.1818, p = 0.0497	R = -0.1541, p = 0.0972	R = -0.1756, p = 0.0582	R = 0.1758, p = 0.0579
SOCS-3	NS	NS	NS	NS	NS	NS	NS	R = -0.1686, p = 0.0693	R = 0.1684, p = 0.0695*
pSTAT3	NS	NS	NS	NS	NS	NS	NS	NS	NS
VEGF	NS	R = 0.2166, p = 0.0230	NS	NS	R = 0.1967, p = 0.0394	NS	R = 0.1967, p = 0.0394	NS	NS

NS: not significant.
*When analysis was performed on a categorical basis SOCS-3 H-score was significantly correlated with shape factor (Mann Whitney U test, p = 0.0286).
**This relationship failed to attain statistical significance in a multivariate model including MVD and IL-8 H-score along with histological grade, the latter emerging as a confounder in the correlation between these two molecules.

ISSN: 1471-2407