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Table 3 Correlations among IL-6, IL-8, CXCR-2, SOCS-3 and VEGF H-score in the entire cohort (Results of Spearman correlation coefficient)

From: The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma

  IL-6 IL-8 CXCR2 SOCS-3 p-STAT-3 VEGF
IL-8 NS*      
CXCR2 R = 0.2393, p = 0.0091*** R = 0.2989, p = 0.0010 NS    
SOCS-3 NS NS NS NS   
p-STAT3 NS NS NS NS NS  
VEGF R = 0.2623, p = 0.0054 R = 0.1217, p = 0.0730 R = 0.3549, p = 0.0001 R = 0.2540, p = 0.0071** NS NS
  1. (NS: not significant).
  2. *IL-6 H-score was marginally higher in the cases positive for IL-8 (Mann Whitney U test, p = 0.0992).
  3. **This correlation failed to attain statistical significance in a multivariate model, including the presence of metastasis, to which both were significantly related.
  4. ***This relationship lost its statistical significance in a multivariate regression model including VEGF.