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Table 5 Multivariate analysis of independent prognostic factors for DSS and OS in patients with invasive carcinoma of the breast (pooled NEC and IMC-NOS)

From: Invasive neuroendocrine carcinoma of the breast: a population-based study from the surveillance, epidemiology and end results (SEER) database

Group DSS   OS  
HR (95% CI) P HR (95% CI) P
Age, years (>60 vs ≤60) 1.14 (1.13-1.16) <0.0001 2.62 (2.60-2.65) <0.0001
Tumor size, mm (>20 vs ≤20) 1.65 (1.64-1.66) <0.0001 1.34 (1.33-1.35) <0.0001
LN (positive vs negative) 1.98 (1.97-2.00) <0.0001 1.64 (1.63-1.65) <0.0001
Grade (III vs I, II) 1.26 (1.25-1.27) <0.0001 1.12 (1.11-1.13) <0.0001
ER status (positive vs negative) 0.82 (0.81-0.83) <0.0001 0.90 (0.89-0.91) <0.0001
PR status (positive vs negative) 0.88 (0.87-0.89) <0.0001 0.93 (0.92-0.94) <0.0001
Neuroendocrine (positive vs negative) 1.80 (1.36-2.37) <0.0001 1.84 (1.50-2.26) <0.0001
Radiation (yes vs no) 0.90 (0.89-0.91) <0.0001 0.75 (0.74-0.76) <0.0001
Surgery (yes vs no) 0.44 (0.43-0.45) <0.0001 0.45 (0.46-0.47) <0.0001
  1. DSS, disease-specific survival; OS, overall survival; NEC; neuroendocrine carcinoma; IMC-NOS, invasive mammary carcinoma, not otherwise specified; HR, hazard ratio; CI, confidence interval; LN, lymph node; ER, estrogen receptor; PR, progesterone receptor.