An explanatory chart of LOH. Eight breast cancer tissues exhibited LOH at all of the informative loci tested at Xq25, and their XCI patterns tended to be non-random. The figure demonstrates the results of LOH by microsatellite analysis at Xq25. The horizontal axis indicates the position of the 11 microsatellite makers and the vertical axis indicates the case numbers of the 22 breast cancers. Legend: Red rectangles, LOH was detected; open rectangles, retention of heterozygosity; blue rectangles, uninformative cases.