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Figure 1 | BMC Cancer

Figure 1

From: Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

Figure 1

Phospho-aspirin-2 inhibits the growth of TNBC cells. A: Left: Chemical structure of phospho-aspirin-2 (PA-2, MDC-22). Right: 24 h-IC50 values of PA-2 and aspirin in TNBC cell lines. B: MDA-MB-231 and BT-20 cells were treated with PA-2 for 24 h and the percentage of proliferating cells was determined by BrdU incorporation. C: MDA-MB-231 and BT-20 cells treated with PA-2 for 24 h were stained with Annexin V/PI, and the percentage of apoptotic cells was determined by flow cytometry. D: PA-2 blocks the G1/S cell cycle phase transition after 24 h treatment in MDA-MB-231 cells, determined by flow cytometry following PI staining.

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BMC Cancer

ISSN: 1471-2407

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