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Table 1 Clinical and histopathological features of pediatric patients with embryonal rhabdomyosarcoma (RMS) (n=19)

From: Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

 

Embryonal RMS n (%)

Sex

 

  Male

11 (58)

  Female

8 (42)

Age (years)

 

  < 10

14 (74)

  ≥ 10

5 (26)

Localisation

 

  Orbit-genitourinary tract-head and neck$

9 (47)

  Cranial paramenigeal-extremity-other$$

10 (53)

Tumor volume

 

  < 5 cm

7 (37)

  ≥ 5 cm

12 (63)

IRS stage

 

  I

2 (10)

  II

3 (16)

  III

11 (58)

  IV

3 (16)

Metastasis

 

  No

16 (84)

  Yes

3 (16)

Recurrence

 

  No

12 (63)

  Yes

7 (37)

Outcome

 

  Alive

13 (68)

  DOD

6 (32)

Expression of markers

 

  EZH2 (positive cells/microscopic field)

40 (range 29-44)

  Ki67 (positive cells/microscopic field)

20 (range 17-29)

  1. Abbreviations: DOD dead of disease, IRS Intergroup Rhabdomyosarcoma Study Group staging system.
  2. $Favorable and $$Unfavorable tumor localization.