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Table 1 Clinical and histopathological features of pediatric patients with embryonal rhabdomyosarcoma (RMS) (n=19)

From: Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

  Embryonal RMS n (%)
Sex  
  Male 11 (58)
  Female 8 (42)
Age (years)  
  < 10 14 (74)
  ≥ 10 5 (26)
Localisation  
  Orbit-genitourinary tract-head and neck$ 9 (47)
  Cranial paramenigeal-extremity-other$$ 10 (53)
Tumor volume  
  < 5 cm 7 (37)
  ≥ 5 cm 12 (63)
IRS stage  
  I 2 (10)
  II 3 (16)
  III 11 (58)
  IV 3 (16)
Metastasis  
  No 16 (84)
  Yes 3 (16)
Recurrence  
  No 12 (63)
  Yes 7 (37)
Outcome  
  Alive 13 (68)
  DOD 6 (32)
Expression of markers  
  EZH2 (positive cells/microscopic field) 40 (range 29-44)
  Ki67 (positive cells/microscopic field) 20 (range 17-29)
  1. Abbreviations: DOD dead of disease, IRS Intergroup Rhabdomyosarcoma Study Group staging system.
  2. $Favorable and $$Unfavorable tumor localization.