Stage and tissue-specific prognostic impact of miR-182 in NSCLC

BMC Cancer

Table 2 miR-182 in tumor cells and stroma as predictors for disease-specific survival in NSCLC patients (univariate analysis; log-rank test) and results of Cox regression analysis summarizing significant independent prognostic factors

Characteristics	Pts (n)	Pts (%)	Median survival (months)	5-year survival (%)	Univariate (P)	Multi-variate (P)	HR (95% CI)
Total (n = 335)					0.062	0.098	0.73
Low	190	57	98	55			(0.50-1.06)
High	115	34	NR	62
Missing	30	9
Pathological stage
Stage I (n = 143)					0.97	NE	NE
Low	87	61	190	73
High	56	39	NR	73
Stage II (n = 127)					0.003	0.020	0.50
Low	80	63	33	39			0.28-0.90
High	47	37	NR	63
Stage III (n = 35)					0.69	NE	NE
Low	23	66	23	39
High	12	34	15	17
Histology
SCC (n = 172)					0.042	0.048	0.57
Low	104	60	NR	58			0.33-0.99
High	68	40	NR	74
AC (n = 106)					0.316	NE	NE
Low	69	65	47	45
High	37	35	57	50
LCC (n = 27)					0.285	NE	NE
Low	17	63	NR	80
High	10	37	58	39

Statistically significant results in bold font.
Abbreviations: NR not reached, PS performance status, SCC squamous cell carcinoma, AC adenocarcinoma, LCC large-cell carcinoma, NE not entered due to insignificance. Adenocarcinoma including cases with bronchioloalveolar carcinoma.

ISSN: 1471-2407