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Table 2 miR-182 in tumor cells and stroma as predictors for disease-specific survival in NSCLC patients (univariate analysis; log-rank test) and results of Cox regression analysis summarizing significant independent prognostic factors

From: Stage and tissue-specific prognostic impact of miR-182 in NSCLC

Characteristics Pts (n) Pts (%) Median survival (months) 5-year survival (%) Univariate (P) Multi-variate (P) HR (95% CI)
Total (n = 335)      0.062 0.098 0.73
  Low 190 57 98 55    (0.50-1.06)
  High 115 34 NR 62    
  Missing 30 9      
Pathological stage        
Stage I (n = 143)      0.97 NE NE
  Low 87 61 190 73    
  High 56 39 NR 73    
Stage II (n = 127)      0.003 0.020 0.50
  Low 80 63 33 39    0.28-0.90
  High 47 37 NR 63    
Stage III (n = 35)      0.69 NE NE
  Low 23 66 23 39    
  High 12 34 15 17  
Histology        
  SCC (n = 172)      0.042 0.048 0.57
  Low 104 60 NR 58    0.33-0.99
  High 68 40 NR 74    
AC (n = 106)      0.316 NE NE
  Low 69 65 47 45    
  High 37 35 57 50    
LCC (n = 27)      0.285 NE NE
  Low 17 63 NR 80    
  High 10 37 58 39    
  1. Statistically significant results in bold font.
  2. Abbreviations: NR not reached, PS performance status, SCC squamous cell carcinoma, AC adenocarcinoma, LCC large-cell carcinoma, NE not entered due to insignificance. Adenocarcinoma including cases with bronchioloalveolar carcinoma.