Figure 5

Maltonis inhibits tumour growth and induces apoptotic cell death in xenograft model of sarcoma. (A) Inhibition of TC-71 tumour growth in nude mice. Mice were treated for two cycles of 5 days with maltonis (1^st cycle: 20 mg/kg or 2^nd cycle: 40 mg/kg) or with vehicle (PBS). Panel shows mean tumour size ± SE of control or treated mice. (B) Morphologic hematoxylin-eosin of fragmented nuclei on tumour-samples derived from two controls (vehicle) or maltonis treated mice (magnification, ×400). (C) TUNEL assay evaluation of apoptotic nuclei after treatment with maltonis (magnification × 200. (D) Representative immunohistochemical evaluation of Ki67 in controls and maltonis treated tumours (magnification ×200).