From: Salvage cytoreductive surgery for patients with recurrent endometrial cancer: a retrospective study
Cases | Deaths | Median OS (months) | UVaanalysis (Pvalue) | |
---|---|---|---|---|
Age at second surgery | 0.549 | |||
≤56 years | 38 | 15 | 60 | |
>56 years | 37 | 15 | 39 | |
ECOG performance status at first surgery | 0.352 | |||
0 | 6 | 1 | 48.00 | |
1 | 62 | 25 | 62.124 | |
2 | 7 | 4 | 34.00 | |
Stage at first surgery (FIGO 2009) | 0.760 | |||
Stage I-II | 58 | 22 | 65.675 | |
Stage III-IV | 17 | 8 | 45.159 | |
Pathological subtype | 0.180 | |||
Endometrioid | 65 | 28 | 57.753 | |
Nonendometrioid | 10 | 2 | 52.10 | |
Histological grade | ||||
I | 14 | 4 | 67.921 | 0.068 |
II | 39 | 15 | 68.006 | 0.040* |
III | 22 | 11 | 44.819 | Reference |
Postoperative therapy after first surgery | 0.309 | |||
Chemotherapy | 33 | 14 | 53.51 | |
Radiotherapy | 5 | 2 | 36 | |
CT+RT | 6 | 1 | 72 | |
Hormonal therapy | 4 | 1 | 114 | |
No | 27 | 12 | 36.196 | |
Symptoms at recurrence | 0.723 | |||
Nonsymptomatic | 30 | 13 | 54 | |
Symptomatic | 45 | 17 | 65 | |
CA125 at recurrence | 0.108 | |||
≤ 35 U/ml | 25 | 7 | 69.650 | |
>35 U/ml | 35 | 18 | 35.733 | |
Not available | 15 | 5 | 77.548 | |
Recurrence detection of nonsymptomatic | 0.134 | |||
Imaging or CA-125 | 17 | 8 | 44.83 | |
Physical examination | 13 | 4 | 96 | |
PFI | 0.032* | |||
≤18 months | 40 | 19 | 34.963 | |
>18 months | 35 | 11 | 76.078 | |
Largest size of recurrence | 0.008* | |||
≤ 6 cm | 36 | 10 | 79.027 | |
> 6 cm | 39 | 20 | 35.918 | |
Multiplicity of recurrence | 0.144 | |||
Solitary | 35 | 12 | 73.219 | |
Multiple | 40 | 18 | 37.295 | |
Site of recurrence | 0.056 | |||
Pelvis b and/or introabdomonal | 63 | 23 | 66.186 | |
Retroperitoneal | 12 | 7 | 30.380 | |
Ascites | 0.048* | |||
None | 67 | 26 | 64.678 | |
Yes | 8 | 4 | 17.171 | |
ECOG performance status before SCR | 0.311 | |||
0 | 30 | 13 | 53.28 | |
1 | 26 | 9 | 109.31 | |
2 | 14 | 5 | 72.0 | |
3 | 5 | 3 | 14.4 | |
Residual disease after SCR | ||||
None | 43 | 12 | 76.462 | 0.000* |
0.1~1 cm | 15 | 6 | 43.825 | 0.001* |
1~2 cm | 6 | 4 | 30.833 | 0.207 |
>2 cm | 11 | 8 | 12.778 | Reference |
Postoperative therapy after SCR | ||||
Chemotherapy | 48 | 22 | 40.192 | Reference |
Radiotherapy | 6 | 1 | 114.0 | 0.045* |
CT+RT | 8 | 3 | 42.0 | 0.764 |
No | 13 | 4 | 72.0 | 0.615 |