RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

Table 4 Multivariable log-linear model and selective associations in leukaemia cases

Measure of association terms	DF	χ²-value^a	P-value^b
RAS*NQO1 ^c	1	1.11	0.29
RAS*MLL	1	0.15	0.70
RAS*SMOKER	1	4.61	0.03
NQO1*MLL	1	0.24	0.62
NQO1*SMOKER	1	4.84	0.03
MLL*SMOKER	1	0.12	0.73

^aχ²-value from the log-likelihood ratio test comparing the submodel without the interaction term with the full model. ^bP-value from the log-likelihood ratio test – Low values indicate that the interaction between the two variables are meaningful in the given population. ^c NQO1 genotype status included allele variants CT and TT. SMOKER: Presence of any smoker in the household; DF: Degrees of Freedom.

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