RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

Table 3 The risk of association of smoking exposures during pregnancy, combining NQO1 and RAS status, in a case-case analysis Brazil, 2000-2010

	NOQ1 ^wt /RAS ^wtn (%)	NOQ1 ^wt /RAS ^mutn (%)	OR (95% CI)	*NOQ1609CT* ^a /RAS ^wtn (%)	OR (95% CI)	NOQ1609CT ^a /RAS ^mutn (%)	OR (95% CI)
Mother ever smoked
No (n,79)	26 (57.8)	13 (56.5)	1^b	29 (74.4)	1^b	11 (64.7)	1^b
Yes (n,45)	19 (42.2)	10 (43.5)	1.05 (0.38-2.90)	10 (25.6)	0.47 (0.19-1.20)	6 (35.3)	0.75 (0.24-2.38)
Mother smoked 3 months before pregnancy
No (n,87)	29 (64.4)	15 (65.2)	1^b	30 (76.9)	1^b	13 (76.5)	1^b
Yes (n,37)	16 (35.6)	8 (34.8)	0.97 (0.34-2.77)	9 (23.1)	0.54 (0.21-1.42)	4 (23.5)	0.56 (0.16-2.00)
Mother smoked during pregnancy
No (n,98)	35 (77.8)	17 (73.9)	1^b	32 (82.1)	1^b	14 (82.4)	1^b
Yes (n,26)	10 (22.2)	6 (26.1)	1.24 (0.39-3.97)	7 (17.9)	0.77 (0.26-2.25)	3 (17.6)	0.75 (0.18-3.14)
Someone in the house ever smoked ^c
No (n,62)	28 (71.8)	10 (45.5)	1^b	18 (46.2)	1^b	6 (37.5)	1^b
Yes (n,54)	11 (28.2)	12 (54.5)	3.06 (1.03-9.07)	21 (53.8)	2.97 (1.16-7.60)	10 (62.5)	4.24 (1.24-14.50)

^a NQ01 genotype status included allele variants CT and TT. ^b1 as a reference. ^cMothers reported the presence of someone smoking at home during the index pregnancy (second-hand smoking). N: number of cases; wt: wild-type; mut: mutation.

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