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Table 3 The risk of association of smoking exposures during pregnancy, combining NQO1 and RAS status, in a case-case analysis Brazil, 2000-2010

From: RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

  NOQ1 wt /RAS wtn (%) NOQ1 wt /RAS mutn (%) OR (95% CI) NOQ1609CT a /RAS wtn (%) OR (95% CI) NOQ1609CT a /RAS mutn (%) OR (95% CI)
Mother ever smoked        
No (n,79) 26 (57.8) 13 (56.5) 1b 29 (74.4) 1b 11 (64.7) 1b
Yes (n,45) 19 (42.2) 10 (43.5) 1.05 (0.38-2.90) 10 (25.6) 0.47 (0.19-1.20) 6 (35.3) 0.75 (0.24-2.38)
Mother smoked 3 months before pregnancy        
No (n,87) 29 (64.4) 15 (65.2) 1b 30 (76.9) 1b 13 (76.5) 1b
Yes (n,37) 16 (35.6) 8 (34.8) 0.97 (0.34-2.77) 9 (23.1) 0.54 (0.21-1.42) 4 (23.5) 0.56 (0.16-2.00)
Mother smoked during pregnancy        
No (n,98) 35 (77.8) 17 (73.9) 1b 32 (82.1) 1b 14 (82.4) 1b
Yes (n,26) 10 (22.2) 6 (26.1) 1.24 (0.39-3.97) 7 (17.9) 0.77 (0.26-2.25) 3 (17.6) 0.75 (0.18-3.14)
Someone in the house ever smoked c        
No (n,62) 28 (71.8) 10 (45.5) 1b 18 (46.2) 1b 6 (37.5) 1b
Yes (n,54) 11 (28.2) 12 (54.5) 3.06 (1.03-9.07) 21 (53.8) 2.97 (1.16-7.60) 10 (62.5) 4.24 (1.24-14.50)
  1. a NQ01 genotype status included allele variants CT and TT. b1 as a reference. cMothers reported the presence of someone smoking at home during the index pregnancy (second-hand smoking). N: number of cases; wt: wild-type; mut: mutation.