Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

Table 1 Statistic summary of the IR-A/IR-B mRNA ratio in 20 types of cancer

Disease		Normal			Tumor
	HIR	LIR	HIR fraction	HIR	LIR	HIR fraction	P value^*
Bladder Urothelial Carcinoma (BLCA)	2	14	0.13	16	106	0.13	0.5
Breast invasive carcinoma (BRCA)	1	106	0.01	140	709	0.16	0
Cervical squamous cell carcinoma and endocervica adenocarcinoma (CESC)	0	2	0	51	65	0.44	0.3
Colon adenocarcinoma (COAD)	3	15	0.17	90	103	0.47	0.014
Glioblastoma multiforme (GBM)	NA	NA	NA	157	12	0.93	NA
Brain Lower Grade Glioma (LGG)	NA	NA	NA	215	5	0.98	NA
Head and Neck squamous cell carcinoma (HNSC)	2	35	0.05	17	286	0.06	0.5
Kidney Chromophobe (KICH)	0	25	0	6	60	0.09	0.139
Kidney renal clear cell carcinoma (KIRC)	0	71	0	27	453	0.06	0.04
Kidney renal papillary cell carcinoma (KIRP)	0	25	0	12	64	0.16	0.039
Acute Myeloid Leukemia (LAML)	NA	NA	NA	173	0	1	NA
Liver hepatocellular carcinoma (LIHC)	0	36	0	9	60	0.13	0.029
Lung adenocarcinoma (LUAD]	4	53	0.07	45	310	0.13	0.158
Lung squamous cell carcinoma (LUSC)	0	35	0	42	218	0.16	0.01
Ovarian serous cystadenocarcinoma (OV)	N/A	N/A	N/A	48	218	0.18	NA
Prostate adenocarcinoma (PRAD)	2	42	0.05	12	164	0.07	0.418
Rectum adenocarcinoma (READ)	0	3	0	23	29	0.44	0.182
Skin Cutaneous Melanoma (SKCM)	NA	NA	NA	87	180	0.33	NA
Thyroid carcinoma (THCA)	3	53	0.05	41	373	0.1	0.197
	0	11	0	102	268	0.28	0.046

The numbers of samples classified as high IR-A/IR-B mRNA ratio (HIR) and low IR-A/IR-B mRNA ratio (LIR) in each tumor type as well as the statistic significances (P value) of the prevalence of HIR samples in each tumor type compared with that in the corresponded normal tissues are indicated in table.
^*Bold font indicates statistically significant results i.e., p-value < 0.05.

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