Distribution of the IR-A/IR-B mRNA ratio in 20 types of cancer evaluated using TCGA RNA-seq database. According to the distribution of IR-A/IR-B mRNA ratio in the adjacent normal, 8 (=23) is selected as the cutoff value to defined the high IR-A/IR-B ratio group (HIR). Acute Myeloid Leukemia (LAML), Bladder Urothelial Carcinoma (BLCA), Glioblastoma multiforme (GMB), Brain Lower Grade Glioma (LGG), Breast invasive carcinoma (BRCA), Colon adenocarcinoma (COAD), Rectum adenocarcinoma (READ) Head and Neck Squamous Cell Carcinoma (HNSC), Prostate adenocarcinoma (PRAD), Ovarian serous cystadenocarcinoma (OV), Thyroid carcinoma (THCA), Uterine Corpus Endometrioid Carcinoma (UCEC), Kidney Chromophobe (KICH), Kidney renal clear cell carcinoma (KIRC), and Kidney renal papillary cell carcinoma (KIRP) were analyzed for expression levels of IR-A and IR-B and grouped according to HIR or LIR. The numbers of patients in each group are indicated in the table, as well as the fraction of patients with HIR. The P value column indicates a statistically significant difference in the prevalence of HIR in a particular tumor type compared to the associated normal tissue using a binomial proportions test.