IR-A/IR-B mRNA ratio in NSCLC and the differentially expressed genes associated with the ratio of IR-A/IR-B mRNA. A. Distribution of the IR-A/IR-B mRNA ratio among the NSCLC and the adjacent normal lung specimens. According to the distribution of IR-A/IR-B mRNA ratio in the adjacent normal lung (the top panel), log2(8) (i.e., 3) was selected as the cutoff value to stratify the subjects into two groups: high IR-A/IR-B ratio (HIR) and low IR-A/IR-B ratio (LIR). B-D. Gene set enrichment analysis (GSEA) of the differentially expressed genes in NSCLC patients with HIR and LIR. GSEA enrichment plots showing that ECM (B) and EMT (C) signaling were down-regulated (p < 0.001, respectively) in LUSC samples with HIR. Additionally, the oxidative phosphorylation pathway was highly enriched in the LUSC samples with HIR (D).