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Table 1 Intra-tumor line heterogeneity: PET and IHC parameters and features

From: Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors

Parameter Texture feature Within line variance
   Total variance
18 F-FDG PET SUV max   0.41
18 F-FDG PET SUV mean   0.33
18 F-FDG PET T/M   0.70
18 F-FDG PET Entropy 0.39
  Skewness 0.58
PIMO   0.77
  Mean 0.77
  Entropy 0.80
  Skewness 0.82
BrdU   0.78
  Mean 0.52
  Entropy 0.58
  Skewness 0.63
pAKT   0.34
  Mean 0.31
  Entropy 0.36
  Skewness 0.47
EGFR   0.29
  Mean 0.15
  Entropy 0.16
  Skewness 0.67
MCT4   0.12
  Mean 0.23
  Entropy 0.20
  Skewness 0.48
CA9   0.08
  Mean 0.24
  Entropy 0.28
  Skewness 0.71
GLUT1   0.47
  Mean 0.92
  Entropy 0.83
  Skewness 0.92
Vascular density   0.40
Perfusion fraction   0.55