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Table 1 Intra-tumor line heterogeneity: PET and IHC parameters and features

From: Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors

Parameter

Texture feature

Within line variance

  

Total variance

18 F-FDG PET SUV max

 

0.41

18 F-FDG PET SUV mean

 

0.33

18 F-FDG PET T/M

 

0.70

18 F-FDG PET

Entropy

0.39

 

Skewness

0.58

PIMO

 

0.77

 

Mean

0.77

 

Entropy

0.80

 

Skewness

0.82

BrdU

 

0.78

 

Mean

0.52

 

Entropy

0.58

 

Skewness

0.63

pAKT

 

0.34

 

Mean

0.31

 

Entropy

0.36

 

Skewness

0.47

EGFR

 

0.29

 

Mean

0.15

 

Entropy

0.16

 

Skewness

0.67

MCT4

 

0.12

 

Mean

0.23

 

Entropy

0.20

 

Skewness

0.48

CA9

 

0.08

 

Mean

0.24

 

Entropy

0.28

 

Skewness

0.71

GLUT1

 

0.47

 

Mean

0.92

 

Entropy

0.83

 

Skewness

0.92

Vascular density

 

0.40

Perfusion fraction

 

0.55