Skip to main content

Table 2 ROC analysis of the selected four 4-probe combinations from the 10 single FISH probe parameters

From: Identification of FISH biomarkers to detect chromosome abnormalities associated with prostate adenocarcinoma in tumour and field effect environment

Probe combination Probe parameters Cut-off 1 Cut-off 2 Cut-off 3 Cut-off 4 Sensitivity Specificity AUC
Probe combination 1 PTEN%loss, CEP7%abnormal, MYC%gain, CEP8%abnormal 33 PTEN% loss 28 CEP7% abnormal 35 MYC% gain 34 CEP8% abnormal 88.20% 84.60% 0.917
Probe combination 2 PTEN/CEP10%loss, CEP7%abnormal, MYC%gain 35 PTEN/CEP10% loss 25 CEP7% abnormal 35 MYC% gain NA 82.40% 80.80% 0.911
Probe combination 3 PTEN/CEP10%loss, CEP7%abnormal, CEP8%abnormal 35 PTEN/CEP10% loss 25 CEP7% abnormal 34 CEP8% abnormal NA 88.20% 80.80% 0.938
Probe combination 4 PTEN/CEP10%loss, MYC%gain, CEP8gain 35 PTEN/CEP10% loss 5 MYC% gain 35 CEP8% gain NA 64.70% 88.50% 0.834
  1. Cut-off 1, cut-off 2, cut-off 3, and cut-off 4 are the optimal probe cut-offs (providing lowest DFI), respectively.