Figure 2
From: Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications
Expression of ERα, Bmi1, p16 INK4a , PR, cyclin D1, pRB and Ki-67 in breast carcinoma. The left column: the representative images for staining of ERα, Bmi1, p16INK4a, PR, cyclin D1, pRB and Ki-67 in non-cancerous breast tissue. The middle column: the representative images for ERα positive breast cancer with Bmi1 positive and p16INK4a negative. The various positive staining of PR, cyclin D1, pRB and low Ki-67 index are presented. The right column was representative images for ERα negative breast cancer with negative Bmi1 but diffuse staining of p16INK4a. The various staining of PR, cyclin D1, pRB and high Ki-67 index are presented, respectively. (Hematoxylin /DAB, × 400).