Genomic instability risk groups in stage 2 and 3 CRCs. Death and risk of relapse were correlated to genomic instability variables. A: Scatter plot integrating nbBP and GGI metrics. Three classes were determined for GGI:low (<0.25), intermediate ([0.25; 0.41[) and high (≥0.41) levels, with high risk associated to intermediate GGI, whereas two classes were defined for nbBP (<116 vs ≥116), with high risk being associated to high number of breakpoints. This produced 6 groups of risk of which one was empty. Tumors within high risk groups are shown as red dots, low risk as blue dots. B: Relapse free survival according to risk groups. C: Overall survival according to risk groups. Red curves correspond to the high risk, blue curves to low risk group.