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Table 4 The difference in treatment response between patient groups of different YAP1 expression is significant: A multivariate Cox proportional hazards regression analysis for YAP expression and treatment interaction based on ER+ breast cancer patients*

From: Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

  

Recurrence-free survival

 

Variable

Category

HR

95% CI

Pvalue

YAP1 expression

Weak, intermediate or strong

1.00

  
 

Absent

1.42

0.56 to 3.59

0.456

Treatment

Control

1.00

  
 

Tamoxifen

0.42

0.26 to 0.68

<0.001

Interaction variable†

Tamoxifen x YAP1 expression

3.51

1.05 to 11.75

0.042

  1. *Other factors included in the analysis are tumour grade (NHG I + II vs. III), nodal status (negative vs. positive) and tumor size (≤ 20 mm vs. >20 mm).
  2. †Interaction variable states if there is a difference in the treatment response in relation to YAP1 expression.
  3. HR = Hazard ratio, CI = Confidence interval, NHG = Nottingham histological grade.
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BMC Cancer

ISSN: 1471-2407

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