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Table 4 The difference in treatment response between patient groups of different YAP1 expression is significant: A multivariate Cox proportional hazards regression analysis for YAP expression and treatment interaction based on ER+ breast cancer patients*

From: Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

   Recurrence-free survival  
Variable Category HR 95% CI Pvalue
YAP1 expression Weak, intermediate or strong 1.00   
  Absent 1.42 0.56 to 3.59 0.456
Treatment Control 1.00   
  Tamoxifen 0.42 0.26 to 0.68 <0.001
Interaction variable Tamoxifen x YAP1 expression 3.51 1.05 to 11.75 0.042
  1. *Other factors included in the analysis are tumour grade (NHG I + II vs. III), nodal status (negative vs. positive) and tumor size (≤ 20 mm vs. >20 mm).
  2. Interaction variable states if there is a difference in the treatment response in relation to YAP1 expression.
  3. HR = Hazard ratio, CI = Confidence interval, NHG = Nottingham histological grade.