Table 3 Correlations of YAP1 mRNA expression and clinical and molecular parameters of the gene expression dataset (n=1107)
| Â | All patients, n=1107 | Â | ER+ patients, n=700 | Â | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | YAP1 mRNA Quartiles | Â | YAP1 mRNA Quartiles | Â | ||||||
| Â | Q1 | Q2 | Q3 | Q4 | Â | Q1 | Q2 | Q3 | Q4 | Â |
Variable | n=277 (%) | n=276 (%) | n=277 (%) | n=277 (%) | p-value | n=175 (%) | n=175 (%) | n=175 (%) | n=175 (%) | p-value |
NHG | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
I | 29 (15) | 43 (24) | 46 (24) | 49 (24) | Â | 17 (15) | 34 (31) | 33 (28) | 38 (30) | Â |
II | 94 (47) | 79 (43) | 77 (40) | 80 (38) | Â | 60 (51) | 48 (44) | 54 (46) | 48 (37) | Â |
III | 77 (38) | 61 (33) | 69 (36) | 80 (38) | 0.355a | 40 (34) | 27 (25) | 31 (26) | 42 (33) | 0.165a |
Lymph node status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Negative | 187 (81) | 207 (87) | 194 (80) | 192 (85) | Â | 138 (80) | 155 (89) | 139 (81) | 138 (79) | Â |
Positive | 44 (19) | 31 (13) | 47 (20) | 35 (15) | 0.715b | 34 (20) | 20 (11) | 32 (19) | 36 (21) | 0.433b |
Tumour size | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
<20 mm | 78 (48) | 85 (54) | 93 (54) | 82 (48) | Â | 55 (45) | 59 (52) | 72 (59) | 76 (56) | Â |
≥20 mm | 86 (52) | 72 (46) | 78 (46) | 88 (52) | 0.917b | 66 (55) | 54 (48) | 50 (41) | 59 (44) | 0.056b |
ERα |  |  |  |  |  |  |  |  |  |  |
<10% | 44 (19) | 57 (24) | 56 (23) | 82 (36) | Â | - | - | - | - | Â |
≥10% | 188 (81) | 180 (76) | 187 (77) | 145 (64) | <0.001b | - | - | - | - |  |
PgR Quartiles | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Q1 | 66 (24) | 62 (22) | 60 (22) | 89 (32) | Â | 51 (29) | 45 (26) | 36 (21) | 43 (25) | Â |
Q2 | 82 (30) | 76 (28) | 60 (22) | 59 (21) | Â | 49 (28) | 48 (27) | 41 (23) | 37 (21) | Â |
Q3 | 76 (27) | 70 (25) | 71 (25) | 60 (22) | Â | 40 (23) | 43 (25) | 48 (27) | 44 (25) | Â |
Q4 | 53 (19) | 68 (25) | 86 (31) | 69 (25) | 0.836a | 35 (20) | 39 (22) | 50 (29) | 51 (29) | 0.011a |
Cyclin D1 Quartiles | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Q1 | 57 (20) | 73 (26) | 66 (24) | 81 (29) | Â | 31 (18) | 45 (26) | 51 (29) | 48 (27) | Â |
Q2 | 41 (15) | 63 (23) | 87 (31) | 85 (31) | Â | 26 (15) | 47 (27) | 53 (30) | 49 (28) | Â |
Q3 | 69 (25) | 69 (25) | 78 (28) | 61 (22) | Â | 47 (27) | 33 (19) | 44 (25) | 51 (29) | Â |
Q4 | 110 (40) | 71 (26) | 46 (17) | 50 (18) | <0.001a | 71 (41) | 50 (28) | 27 (16) | 27 (16) | <0.001a |