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Table 3 Correlations of YAP1 mRNA expression and clinical and molecular parameters of the gene expression dataset (n=1107)

From: Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

  All patients, n=1107   ER+ patients, n=700  
  YAP1 mRNA Quartiles   YAP1 mRNA Quartiles  
  Q1 Q2 Q3 Q4   Q1 Q2 Q3 Q4  
Variable n=277 (%) n=276 (%) n=277 (%) n=277 (%) p-value n=175 (%) n=175 (%) n=175 (%) n=175 (%) p-value
NHG           
I 29 (15) 43 (24) 46 (24) 49 (24)   17 (15) 34 (31) 33 (28) 38 (30)  
II 94 (47) 79 (43) 77 (40) 80 (38)   60 (51) 48 (44) 54 (46) 48 (37)  
III 77 (38) 61 (33) 69 (36) 80 (38) 0.355a 40 (34) 27 (25) 31 (26) 42 (33) 0.165a
Lymph node status           
Negative 187 (81) 207 (87) 194 (80) 192 (85)   138 (80) 155 (89) 139 (81) 138 (79)  
Positive 44 (19) 31 (13) 47 (20) 35 (15) 0.715b 34 (20) 20 (11) 32 (19) 36 (21) 0.433b
Tumour size           
<20 mm 78 (48) 85 (54) 93 (54) 82 (48)   55 (45) 59 (52) 72 (59) 76 (56)  
≥20 mm 86 (52) 72 (46) 78 (46) 88 (52) 0.917b 66 (55) 54 (48) 50 (41) 59 (44) 0.056b
ERα           
<10% 44 (19) 57 (24) 56 (23) 82 (36)   - - - -  
≥10% 188 (81) 180 (76) 187 (77) 145 (64) <0.001b - - - -  
PgR Quartiles           
Q1 66 (24) 62 (22) 60 (22) 89 (32)   51 (29) 45 (26) 36 (21) 43 (25)  
Q2 82 (30) 76 (28) 60 (22) 59 (21)   49 (28) 48 (27) 41 (23) 37 (21)  
Q3 76 (27) 70 (25) 71 (25) 60 (22)   40 (23) 43 (25) 48 (27) 44 (25)  
Q4 53 (19) 68 (25) 86 (31) 69 (25) 0.836a 35 (20) 39 (22) 50 (29) 51 (29) 0.011a
Cyclin D1 Quartiles           
Q1 57 (20) 73 (26) 66 (24) 81 (29)   31 (18) 45 (26) 51 (29) 48 (27)  
Q2 41 (15) 63 (23) 87 (31) 85 (31)   26 (15) 47 (27) 53 (30) 49 (28)  
Q3 69 (25) 69 (25) 78 (28) 61 (22)   47 (27) 33 (19) 44 (25) 51 (29)  
Q4 110 (40) 71 (26) 46 (17) 50 (18) <0.001a 71 (41) 50 (28) 27 (16) 27 (16) <0.001a
  1. NHG=Nottingham Histological Grade, ER=Estrogen receptor, PgR=Progesterone receptor.
  2. aSpearman´s rank correlation.
  3. bMann–Whitney U test.